Josh Siegle and Matt Wilson have authored the first paper based on data collected with the Open Ephys system. "Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus" appeared in eLife in July 2014. In their experiments, Siegle & Wilson used closed-loop optogenetic feedback to alter behavior in mice performing a spatial navigation task. The Open Ephys software and hardware were designed with this type of experiment in mind. The lightweight headstage and cable did not impinge animals' movement, while the modular software made it simple to incorporate algorithms for triggering stimulation at specific phases of the theta rhythm. The experiments also incorporated a dual-site flexDrive capable of simultaneously targeting both sides of the hippocampus. We're looking forward to many more papers based on Open Ephys data in the future!